Hi...
My Mom mentioned the other day that, when she was a child, one of her neighbours was the fantastic musician, Jackie Washington!
She said she used to love falling asleep while listening to him play and sing, almost always also accompanied by several members of his family and friends. Lucky Lady!!! :-)
Take a listen:
http://borealisrecords.com/products-page/jackie-washington/well-meet-again/ |
So, while you're listening to Jackie...
here's the answer to the question of what Stem Cell Research, Insulin, and the CN Tower have in common:
They all have their origin in Toronto, Ontario.
"Till, McCulloch lauded for work as fathers of stem cell science.
Fifty years ago today, two young, unknown scientists at the University of Toronto and the fledgling Ontario Cancer Institute (OCI) published accidental findings that proved the existence of stem cells - cells that can self-renew repeatedly for different uses.
Today, acclaimed the world over as the “fathers of stem cell science,” Drs. James Till, a biophysicist, and Ernest McCulloch, a hematologist,..Their work changed the course of cancer research and lit the way to what we now call regenerative medicine - the use of stem cells for bone marrow transplants and many other types of disease research,”...
Over the years, international excitement generated by the stem cell discovery has inspired and attracted many talented scientists to Toronto the study with Till and McCulloch at OCI and the University.
“Toronto is truly the city where stem cell science was born, thanks to Till and McCulloch,” said Paige.
“The promise of stem cell research for healing and helping humanity is the great living legacy of Professors Till and McCulloch."
Source: http://www.facmed.utoronto.ca/about/communications/news/U_of_T_celebrates_50_years_of_stem_cell_research.
http://www.utoronto.ca/gairdner50th.htm |
Hey kids!
Did you notice where the article mentioned that this world-changing scientific discovery was the result of "accidental findings" ?
Sarah and Madisson did.
Learning this information was one of their own "accidental findings" which led them to write their book called "They Don't Call It 'The Golden Horseshoe for Nuthin'!" --- the one you're reading right now! :-)
Okay, so moving on to learn about another "accidental finding". This one led to the discovery of Insulin! (I've pasted an entire article below because it discusses how dogs helped people with diabetes and how Banting did not give up on his idea and his dreams! See the paragraph in brownish-red print)
Oh by the way, this research, experimentation and world-changing, Nobel Prize-winning discovery took place at The University of Toronto!
The Discovery of Insulin
Before the discovery of insulin, diabetes was a feared disease that most certainly led to death. Doctors knew that sugar worsened the condition of diabetic patients and that the most effective treatment was to put the patients on very strict diets where sugar intake was kept to a minimum. At best, this treatment could buy patients a few extra years, but it never saved them. In some cases, the harsh diets even caused patients to die of starvation.
In 1889 in Germany, physiologist Oskar Minkowski and physician Joseph von Mering, showed that if the pancreas was removed from a dog, the animal got diabetes. But if the duct through which the pancreatic juices flow to the intestine was ligated - surgically tied off so the juices couldn't reach the intestine - the dog developed minor digestive problems but no diabetes. So it seemed that the pancreas must have at least two functions:
- To produce digestive juices
- To produce a substance that regulates the sugar glucose
This hypothetical internal secretion was the key. If a substance could actually be isolated, the mystery of diabetes would be solved. Progress, however, was slow.
Banting's Idea
In October 1920 in Toronto, Canada, Dr. Frederick Banting, an unknown surgeon with a bachelor's degree in medicine, had the idea that the pancreatic digestive juices could be harmful to the secretion of the pancreas produced by the islets of Langerhans.
He therefore wanted to ligate the pancreatic ducts in order to stop the flow of nourishment to the pancreas. This would cause the pancreas to degenerate, making it shrink and lose its ability to secrete the digestive juices. The cells thought to produce an antidiabetic secretion could then be extracted from the pancreas without being harmed.
Early in 1921, Banting took his idea to Professor John Macleod at the University of Toronto, who was a leading figure in the study of diabetes in Canada. Macleod didn't think much of Banting's theories. Despite this, Banting managed to convince him that his idea was worth trying. Macleod gave Banting a laboratory with a minimum of equipment and ten dogs. Banting also got an assistant, a medical student by the name of Charles Best. The experiment was set to start in the summer of 1921.
Banting, right, and Best, left, with one of the diabetic dogs used in experiments with insulin. Credits: University of Toronto Archives |
The Experiment Begins
Banting and Best began their experiments by removing the pancreas from a dog. This resulted in the following:
- It's blood sugar rose.
- It became thirsty, drank lots of water, and urinated more often.
- It became weaker and weaker.
The dog had developed diabetes.
Experimenting on another dog, Banting and Best surgically ligated the pancreas, stopping the flow of nourishment, so that the pancreas degenerated.
After a while, they removed the pancreas, sliced it up, and froze the pieces in a mixture of water and salts. When the pieces were half frozen, they were ground up and filtered. The isolated substance was named "isletin."
The extract was injected into the diabetic dog. Its blood glucose level dropped, and it seemed healthier and stronger. By giving the diabetic dog a few injections a day, Banting and Best could keep it healthy and free of symptoms.
Banting and Best showed their result to Macleod, who was impressed, but he wanted more tests to prove that their pancreatic extract really worked.
Banting's and Best's laboratory, where insulin was discovered. Credits: University of Toronto Archives |
Extended Tests
For the increased testing, Banting and Best realized that they required a larger supply of organs than their dogs could provide, and they started using pancreases from cattle. With this new source, they managed to produce enough extract to keep several diabetic dogs alive.
In late 1921, a third person, biochemist Bertram Collip, joined the team. Collip was given the task of trying to purify the insulin so that it would be clean enough for testing on humans.
During the intensified testing, the team also realized that the process of shrinking the pancreases had been unnecessary. Using whole fresh pancreases from adult animals worked just as well.
Testing on Humans
The team was eager to start testing on humans. But on whom should they test? Banting and Best began by injecting themselves with the extract. They felt weak and dizzy, but they were not harmed.
Collip continued his work to purify the insulin. He also experimented with trying to find the correct dosage. He learned how to diminish the effect of an insulin overdose with glucose in different forms. He discovered that the glucose should be as pure as possible. Orange juice and honey are good examples of foods rich in glucose.
The Nobel Prize
The news of the successful treatment of diabetes with insulin rapidly spread outside of Toronto, and in 1923 the Nobel Committee decided to award Banting and Macleod the Nobel Prize in Physiology or Medicine.
The decision of the Nobel Committee made Banting furious. He felt that the prize should have been shared between him and Best, and not between him and Macleod. To give credit to Best, Banting decided to share his cash award with him. Macleod, in turn, shared his cash award with Collip.
The Nobel Prize in Physiology or Medicine for insulin has been much debated. It has been questioned why Macleod received the prize instead of Best and Collip. However, Macleod played a central role in the discovery of insulin. It was he who supported the project from the beginning. He supervised the work and it is also most likely that Macleod's contacts in the scientific world helped the team in getting a speedy recognition of their discovery.
Frederick G. Banting and John Macleod were awarded the Nobel Prize in Physiology or Medicine in 1923 "for the discovery of insulin." |
The Legacy of Insulin
Banting, Macleod, and the rest of the team patented their insulin extract but gave away all their rights to the University of Toronto, which would later use the income from insulin to fund new research.
Very soon after the discovery of insulin, the medical firm Eli Lilly started large-scale production of the extract. As soon as 1923, the firm was producing enough insulin to supply the entire North American continent.
Although insulin doesn't cure diabetes, it's one of the biggest discoveries in medicine. When it came, it was like a miracle. People with severe diabetes and only days left to live were saved. And as long as they kept getting their insulin, they could live an almost normal life.
Source: http://www.nobelprize.org/educational/medicine/insulin/discovery-insulin.html
So, now on to the CN TOWER!!! (in Toronto, of course)
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Below is a view of the middle of the Golden Horseshoe as seen from the CN Tower, Toronto & you can also see some of Hamilton's lights in the upper right portion:
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'til then...
Patti Zonta